"Rehabilitation of sensory, motor or cognitive impairments in brain-damaged patients"
(pdf CRNL 2012 Call)

The newly-inaugurated Lyon Neuroscience Research Centre (CRNL, http://crnl.univ-lyon1.fr/index.php/en), France, is seeking to attract a neuroscientist (any nationality) to establish a new research team that will complement and extend existing research strengths in human cognitive and clinical neuroscience.
Position profile:
We seek to attract a neuroscientist who will have the opportunity to establish a permanent research position at the CRNL. The selected candidate will be supported to compete for initial funding (for 2 years) from the Fondation pour la Recherche Medicale ‘Amorcage jeunes equipes’ funding scheme
(for further information see the FRM website: http://www.frm.org/images/pdf/aides_scientif/frm_ao_amorcage2012.pdf). The aim of this FRM
scheme is to support outstanding candidates while they are in the process of securing a permanent position through the University, INSERM or CNRS. The successful candidate will establish a new team at CRNL, will be hosted in the ImpAct group*, and will receive up to 300k euros over 2 years to fund their personal salary, a post-doc position and research expenses.
Candidate profile:
Applicants should have an outstanding publication record in international journals and a record of obtaining nationally and internationally competitive research grants. They should be at an early career stage (having already held at least one postdoc position). They should bring an independent program
of research that offers new methodological expertise to the centre (especially in neuroimaging, brain stimulation, neural rehabilitation) and will establish close collaborative links with CRNL teams and local hospitals. This call is particularly focused on research with clinical translational potentialthat aims to benefit patients with neurological disorders. To further strengthen local expertise we
especially welcome candidates whose research focuses on the rehabilitation of sensory, motor or cognitive impairments in brain-damaged patients.
Application procedure and timeline:
Interested candidates are invited to submit their applications by email to: call2012.crnl-lyon@inserm.fr by the deadline of Friday, July 7th 2012. Applications should consist of a CV (max.2 pages), publications list, and a description of the proposed research program (max. 3 pages).
Selected candidates will be invited for an interview or a video conference by a panel of international experts during the week of July 23rd-27th 2012. The successful candidate’s dossier will then be forwarded for funding consideration to FRM with a supportive recommendation letter from the CRNL.
The final decision by the FRM is expected by the end of September 2012.

Information about CRNL:
Since January 2011, the Lyon Neuroscience Research Center integrates the multi-disciplinary expertise of 11 teams (350 members stemming from Inserm, CNRS and University Lyon 1 laboratories) making possible a synergistic approach on integrative and cognitive neurophysiology and related brain disorders. The neural and molecular substrates of brain functions, from sensory and motor processes to cognition and mind, are investigated along two entwined strategic directions: from gene and cell to behavior, and from bench to patient. Our aim is to bridge the gaps between the different levels of brain understanding, and at reinforcing a translational research with reciprocal
exchanges between basic conceptual advances and clinical challenges. You can find out more information about centre teams here: http://crnl.univ-lyon1.fr
Further information on this call can be obtained via:
call2012.crnl-lyon@inserm.fr
*Hosting team at CRNL: ImpAct : Integrative Multisensory Perception Action and Cognition team

Congenital amusia in Lyon, France
We are seeking applicants for a 2-year post-doctoral position that integrates into our research project on congenital amusia funded by the French National Agency of Research.
The post-doctoral researcher will work with Barbara Tillmann (Auditory Cognition and Psychoacoustics team) and Anne Caclin (Brain Dynamics and Cognition team) at the Lyon Neuroscience Research Center, and will conduct behavioral and EEG/MEG experiments investigating the cognitive and neural correlates of this musical deficit.

Candidates should hold a PhD in neuroscience, experimental psychology, or a related field, and are invited to send a CV, a statement of research interests, and the names of two references to btillmann@olfac.univ-lyon1.fr and anne.caclin@inserm.fr. Interest in auditory perception, music cognition and brain imaging would be a plus. The starting date is flexible, but no later than January 1st, 2013. Application will close on July 1st 2012 or when the position is filled.

"Role of mutations in snRNA components of the spliceosome in brain development and survival"

Project summary : our research group has recently identified mutations in U4atac snRNA component of the U12 spliceosome in patients affected with severe brain malformations, learning deficiencies and early postntal death (Ref.1 and 2). We are currently undertaking whole transcriptome studies on patients' cells to characterize precisely U12 intron splicing defects and to identify abnormally expressed genes containing U12 introns and their targets involved in brain development and survival. We also plan to do a conditional mouse model harbouring the recurrent U4atac snRNA mutation to characterize the sequence of abnormal events leading to brain malformations. Several other approaches aiming at characterizing the molecular mechanisms leading to the splicing defect in patients' cells are currently undertaken through collaborative studies.

Required skills and experience

We offer a post-doctoral position to an applicant with strong skills in genetics and background in molecular biology, bioinformatics, genomics or translational science/clinical research. Our genetics group is part of the TIGER team (Dr Laurent Bezin, Pr Philippe Ryvlin) of the Lyon Neuroscience Research Center (Dr Olivier Bertrand). Our team covers the fields of genetics, genomics, transcriptomics, neuroimaging and cell biology as well as clinical aspects aiming at characterizing the mechanisms involved in brain development and cognition.

Funding

A 3-year post-doctoral position is available from January, 2012 at the Lyon Neuroscience Research Center, which offers a stimulating, young and international environment with state of the art facilities. For details, see: http://ifnl.univ-lyon1.fr/files/documents/LNRC.pdf

1. Edery P, Marcaillou C, Sahbatou M, Labalme A, Chastang J, Touraine R, Tubacher E, Senni F, Bober MB, Nampoothiri S, Jouk PS, Steichen E, Berland S, Toutain A, Wise CA, Sanlaville D, Rousseau F, Clerget-Darpoux F, Leutenegger AL. Association of TALS developmental disorder with defect in minor splicing component U4atac snRNA. Science. 2011 Apr 8;332(6026):240-3.

2. Leutenegger AL, Labalme A, Genin E, Toutain A, Steichen E, Clerget-Darpoux F, Edery P. Using genomic inbreeding coefficient estimates for homozygosity mapping of rare recessive traits: application to Taybi-Linder syndrome. Am J Hum Genet. 2006 Jul;79(1):62-6.

Contact: Patrick Edery, patrick.edery@chu-lyon.fr

Patrick Edery, MD, PhD,

Professor, Medical Genetics

Medical Genetics Service

Groupement Hospitalier Est

HFME/CBPE, 6th Floor

59, Boulevard PINEL

69677 BRON cedex

FRANCE

Tel 00 33 4 72 12 96 98

Secretary : 00 33 4 72 12 96 39 (or 96 40)

Fax : 00 33 4 72 12 97 10

Email: patrick.edery@chu-lyon.fr or charles.edery@chu-lyon.fr

 "Dynamics of the neuronal network controlling sleep and waking"

"Mammalian sleep comprises two major phases, slow-wave sleep (SWS) and paradoxical sleep (PS) also called rapid eye-movement sleep (REM) or dream sleep. These two sleep stages alternate with waking in a cyclic way and a constant order (PS always follows SWS) and rely on a network of cerebral structures that are numerous and distributed throughout the entire neuraxis: waking structures, formed by the monoaminergic, cholinergic, and orexinergic neurons, SWS structures within the lateral and ventrolateral preoptic area, and PS structures, initially limited to the pons and formed by the dorsal subcoeruleus nucleus and the pontine tegmental nuclei. To date however, the specific role of each of these areas, and their functional interactions at the origin of the alternation of vigilance states remain unknown. This partially explains the lack of a relevant plausible models that can reliably account for the functional organization of this complex network and its dynamics. In this context, our project aims at the characterization of the dynamics of the neuronal interactions within the sleep-wake network. An experimental approach using multi-electrodes will be used to determine the mechanisms underlying drowsiness and maintenance of SWS, and those controlling the activity of the PS executive neurons by simultaneously recording unit and LFP signals in the key areas responsible for PS and SWS.

Postdoctoral candidates with strong expertise in multi-electrode recordings and data analysis are welcome to apply to reinforce our team and the bundle of competence and techniques already present (extra- and intracellular recordings in rats and mice, track-tracing, functional anatomy studies and proteogenomics, DNA chips, transgenic mice, small animal MRI)"

Contact : Damien Gervasoni, PhD, Chargé de Recherche
Equipe Physiopathologie des Réseaux Neuronaux du Cycle Veille-Sommeil Centre de Recherche en Neurosciences de Lyon (INSERM U1028 - CNRS U5292 - Université Claude Bernard)
Faculté de Médecine Laënnec
7 rue Guillaume Paradin
69372 Lyon, cedex 08, FRANCE
T (+33) 4 78 78 57 98 (direct)
T (+33) 4 78 77 10 40
F (+33) 4 78 77 10 22

Neural dynamics of episodic memory

Abstract: The overall objective is to develop a novel approach in animals of how central features of episodic memories are encoded, stored and dynamically reorganized with time in selected regions and circuits of the mammalian brain. This project will combine  molecular, cellular, electrophysiological and behavioural approaches specifically designed to decipher how manipulation of key molecular/cellular mechanisms influence the formation of neural codes, network properties and cognitive outcomes during the processes of forming and recalling episodic memories. We will use novel behavioural protocols to assess features of episodic memory; multiple-sites network oscillations recordings and synchronization analysis, single-cell recording technology in vivo, experimental manipulation of specific cell types (newborn hippocampal neurons) and gene targeting.

The post-doctoral fellow will study the dynamics of network formation during learning by recording neural oscillations in relevant structures of the hippocampus (DG and CA1, ventral and dorsal regions), prefrontal area and olfactory cortex. Further analysis will be performed to detect spatiotemporal patterns of neural coherence between structures. Their reactivation during recall of different combinations of the learned associations will be studied to test if, and for what type of information, recall of recent and remote memory is associated with similar or distinct patterns of neuronal coherence between structures.

Methodologically, temporally structured activity in neural ensembles will be detected by recording LFP activities, reflecting the summated activity of dendritic currents, an optimal method for coherent activity detection in vivo. Indeed, synchronized rhythmic activities in neural networks can be detected as LFP oscillations in a given frequency band. These oscillations underlie functional interactions between neurons at the local as well as distributed levels and, as seen above, are believed to serve memory processing by promoting and coordinating the timing of neural firing.

Personne à contacter: Nadine Ravel (nravel@olfac.univ-lyon1.fr)

Experimental skills:

Animal Behavior

Stereotaxic implantation techniques

Electrophysiological recordings or pharmacology on behaving animals

Signal processing training will be an added value

Fundings:

The post-doctoral position is included in a larger project funded for 4 years by the French National Research Agency.  A 22 months post-doc fund has been included in the project and is already acquired.

Starting date:

January or at least the first third of 2012.

The focus of the position is on EEG data acquisition and analysis to identify the neurophysiological correlates of attention and vigilance, in relation to the evolution of performances in various cognitive paradigms.

The post-doctoral fellow will be part of a three years multi-partner project that started in September 2011 and whose objective is the EEG monitoring for the anticipation of cognitive and physical human performances.

The candidates should have a PhD in Neuroimaging, Human electrophysiology, Cognitive neuroscience, Biomedical Engineering or a related area. Experience with high density EEG in humans is highly desirable (acquisition, processing, statistics) as well as programming skills (Matlab).  Application from candidates with previous experience or special interest in related fields such as real-time electrophysiology, brain-computer interfaces and neurofeedback training are welcome.

The Lyon Neuroscience Research Center integrates the multidisciplinary expertise of 14 teams (about 350 researchers), including university-researchers, clinician-researchers, technicians and engineers, doctoral and post-doctoral fellows,making possible a synergistic approach on integrative and cognitive neurophysiology and its related braindisorders.The neural and molecular substrates of brain functions, from sensory and motor processes to cognition andmind, are investigated along two entwined strategic directions: from gene to behavior, and from benchto patient. Our aim is to bridge the gaps between the different levels of investigation, and to reinforce atranslational research with reciprocal exchanges between basic conceptual advances and clinical challenges. The Neuroimaging facilities include an EEG, MEG, TMS, MR and PET scans as well as access to SEEG recordings in epileptic patients.

Contact : Jérémie Mattout

Please address questions or send CV, letter of application with research interests, and two references to Jérémie Mattout (jeremie.mattout@inserm.fr) at the Brain Dynamics and Cognition Team, in the Lyon Neuroscience Research Center, in France.Applications will be considered until position is filled. Starting date is negotiable, though it can begin as early as November 2011.

Recherche Technicien de laboratoire (BAP A) pour 3 mois de vacations temps plein (1er octobre - 31 décembre)
Encadré par un ingénieur, au sein d'une plateforme de Neurogénétique Fonctionnelle, le technicien participera activement aux projets des différentes équipes du Centre de Recherche en Neurosciences de Lyon (U1028) qui souhaitent développer des outils de biologie moléculaires.
·           Conduire, en adaptant les conditions expérimentales, un ensemble de techniques de biologie cellulaire et moléculaire (culture de cellules, transfection, PCR, clonage, transformation, miniprep, maxiprep...)
·           Formaliser et actualiser les protocoles techniques utilisés
·           Préparer l'appareillage et des solutions (milieu de culture bactérien et cellulaires, boites de gélose,...)
·           Avoir des connaissances théoriques et pratiques en techniques courantes de biologie moléculaires et cellulaires
·           Une connaissance du clonage serait très appréciée

Poste situé à: Faculté de Médecine R.T.H. Laennec - 7 rue Guillaume Paradin 69372 Lyon Cedex 08

Contacts:
Scientifique:
Claire BENETOLLO
claire.benetollo@inserm.fr
Tel: 04 78 77 86 15
Administratif:
Alain ESCODA
alain.escoda@inserm.fr
Tel: 04 72 68 49 60

22/07/2011: Offre de thèse CIBLE

Traitement hédonique des molécules odorantes : approches psychophysiques et neurobiologiques

Type de financement : ADR Région Rhône-Alpes (Programme CIBLE 2011) - Télécharger l'offre

Equipe CRNL "Neuroplasticité et Neuropathologie de la Perception Olfactive" - Contact : Dr. Moustafa BENSAFI

Post-doctoral scientist position
Authors: Michel Hoen (CRNL)  & Emmanuel Procyk (U846)

A 2-years post-doctoral position in electrophysiological study of auditory and sequence processing in the rhesus monkey (macaca mulatta) is now opened at the Stem-Cell and Brain Research Institute, in Lyons, France (Inserm U846 - http://www.sbri.fr/ - Dir. Henry Kennedy),

under the co-supervision of Ph.D. Emmanuel Procyk (U846) and Ph.D. Michel Hoen (Centre de Recherche en Neuroscience de Lyon - U1028/UMR5292 Univ Lyon1) .

The position is opened in the context of a bilateral French-German funded research project, involving scientific collaborations between the SBRI laboratory in France and the Group of Professor Sonja Kotz at the Max Plank Institute for human cognitive and brain sciences in Leipzig, Germany (http://www.cbs.mpg.de).
We are looking for a talented and motivated post-doctoral fellow. The ideal candidate should have a PhD or equivalent degree in neuroscience, experimental psychology or comparable fields. Experience with behavioural or electrophysiological research in monkeys is desired but not mandatory. Past experience in the domain of auditory processing (generation and delivery of auditory stimuli) or research using electrophysiological approaches in humans would be an advantage.
To apply or obtain further information, please email to michel.hoen@inserm.fr: an application letter including a letter describing past research experience and a copy of your CV and full publications list and any other document you would judge informative.