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Invités 2016 Emmanuel PINTEAUX, 29 février Edi BARKAI, 21 mars Fabrizio DORICCHI , 18 avril Yu HAYASHI, 30 mai Anita LUTHI, 20 juin |
Lundi 5 décembre 2016 à 12 h : Bruno Truchet : "La question à un million d’euros : LTP= Mémoire ?"
lieu : Amphithéâtre Margaux Hemingway , Bâtiment IDEE, situé à l'entrée Est du Groupement Hospitalier Est, 59 Bd Pinel (accès boulevard Laurent-Bonnevay) à Bron
invité par les équipes CMO et FORGETTING
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Bruno Turchet PhD, MCU, Laboratoire de Neurosciences Cognitives UMR7291, Université Aix-Marseille |
Thématique de recherche
Son travail est centré sur l’étude des bases neurales de la cognition spatiale
. Kv4 potassium channels modulate hippocampal EPSP-spike potentiation and spatial memory in rats. Truchet B, Manrique C, Sreng L, Chaillan FA, Roman FS, Mourre C. Learn Mem. 2012 Jun 14;19(7):282-93.
. Learning and memory of cue-reward association meaning by modifications of synaptic efficacy in dentate gyrus and piriform cortex. Truchet B, Chaillan FA, Soumireu-Mourat B, Roman FS. Hippocampus. 2002;12(5):600-8.
. Early integrative processes physiologically observed in dentate gyrus during an olfactory associative training in rat. Truchet B, Chaillan FA, Soumireu-Mourat B, Roman FS. J Integr Neurosci. 2002 Jun;1(1):101-15.
Lundi 20 juin 2016 à 12 h : Anita Lüthi : "Coordinated infra-slow neural and cardiac oscillations mark fragility and off-line periods in mammalian sleep"
lieu : Amphithéâtre Margaux Hemingway , Bâtiment IDEE, situé à l'entrée Est du Groupement Hospitalier Est, 59 Bd Pinel (accès boulevard Laurent-Bonnevay) à Bron
invitée par Christelle Peyron (SLEEP) et Hélène BASTUJI (NEUROPAIN)
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Anita Lüthi Prof associée, Unil, Lausanne, Suisse |
Thématique de recherche
Son travail est centré sur l’étude des oscillations thalamo-corticale, les entrées sensorielles pendant le sommeil et les sleep-spindles
. Phasic, nonsynaptic GABA-A receptor-mediated inhibition entrains thalamocortical oscillations. Rovó Z, Mátyás F, Barthó P, Slézia A, Lecci S, Pellegrini C, Astori S, Dávid C, Hangya B, Lüthi A, Acsády L. J Neurosci. 2014 May 21;34(21):7137-47.
. Manipulating sleep spindles--expanding views on sleep, memory, and disease. Astori S, Wimmer RD, Lüthi A. Trends Neurosci. 2013 Dec;36(12):738-48.
Lundi 30 mai 2016 à 12h - Yu Hayashi : "Genetic dissection of the paradoxical (REM) sleep center"
lieu : Amphithéâtre Margaux Hemingway , Bâtiment IDEE, situé à l'entrée Est du Groupement Hospitalier Est, 59 Bd Pinel (accès boulevard Laurent-Bonnevay) à Bron
invité par JS LIN (WAKING), christelle PEYRON (SLEEP) et Paul SALIN (FORGETTING)
Yu Hayashi PhD, International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Ibaraki, Japon |
Thématique de recherche
embryonic cell lineage, DREADD technology, REM center and function
Cells of a common developmental origin regulate REM/non-REM sleep and wakefulness in mice, Y. Hayashi, M. Kashiwagi, K. Yasuda, R. Ando, M. Kanuka, K. Sakai, S. Itohara, Science 20 November 2015: Vol. 350 no. 6263 pp. 957-961
Lundi 18 avril 2016 à 12h - Fabrizio DORICCHI : "Expectancy, spatial attention and consciousness"
lieu : Amphithéâtre Margaux Hemingway, Bâtiment U$IDEE, situé à l'entrée Est du Goupement Hospitalier Est, 59 Bd Pinel (accès boulevard Laurent-Bonnevay) à Bron
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Fabrizio Doricchi |
Abstract
Rather than passively responding to sensory stimuli, the human brain actively picks up and exploits the statistical regularities that govern the appearance of stimuli in space and time. These regularities allow generating predictions about incoming inputs and minimizing the discrepancy between predicted and observed sensory events. In this seminar I’ll discuss recent neuropsychological, electrophysiological and fMRI investigations from our lab, showing how attentional control and conscious processing are modulated by the spatial and timing regularities of attentional events, i.e. the predictive context. First,I’ll highlight the crucial influence played by spatial-probabilistic expectancies on brain responses related to the endogenous-anticipatory orienting of attention and to the detection of attentional targets.These studies also provide the first evidence of the selective reorienting response of the left hemisphere to invalidly cued targets in the right side of space. In a second step, I’ll discuss clinical investigations documenting the anatomical correlates of spatially modulated deficits of reward learning in right brain damage (“motivational neglect”). Third, I’ll summarise a recent ERPs study showing that the probabilistic occurrence and the timing of consciously perceived stimuli modifies adaptively the access to awareness of stimuli that, within the same task, usually go unseen.Finally, I’ll try to focus on relevant open questions to be addressed in future studies.
Lundi 21 mars 2016 à 12h - Edi BARKAI : "Learning-induced modulation of intrinsic neuronal excitability : mechanism and functional significance"
lieu : Amphithéâtre Margaux Hemingway , Bâtiment IDEE, situé à l'entrée Est du Groupement Hospitalier Est, 59 Bd Pinel (accès boulevard Laurent-Bonnevay) à Bron
invité par Nadine RAVEL (CMO) et Paul SALIN (FLUID)
La conférence sera suivie d'un workshop sur la plasticité : voir le programme
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Edi Barkai Professeur, directeur du laboratoire « Neurobiology of Learning and Memory », Université d’Haifa, Israel http://brain.haifa.ac.il/HTML/HTMLEng/edi2.html |
Abstract
Learning-induced enhancement in neuronal excitability is evident in hippocampal, amygdala and piriform cortex pyramidal neurons following a complex olfactory-discrimination operant conditioning task. Such enhanced excitability is manifested in reduced spike frequency adaptation that results from reduction in the slow afterhyperpolarization (AHP), which develops after a burst of action potentials. AHP reduction is apparent throughout the pyramidal cells neuronal population.
The post-burst AHP reduction is mediated by decreased conductance for calcium-dependent potassium current, the sIAHP. This long-lasting reduction is dependent on persistent activation of the PKC and ERK second messenger systems. Similar long-lasting AHP reduction can be induced in-vitro by repetitive synaptic stimulation or by kainate application. Such activity-dependent AHP reduction is occluded by prior learning.
Olfactory-learning induced enhanced neuronal excitability in CA1 pyramidal neurons is also accompanied by enhanced learning capability in a novel hippocampus-dependent task, the Morris water maze.
We suggested that AHP reduction is the cellular mechanism that enables neuronal ensembles to enter into a state which may be best termed "learning mode". This state lasts for up to several days and its behavioral manifestation is enhanced learning capability in tasks that depend on these particular neuronal ensembles.
Thématique de recherche
Our primary interest is the cellular mechanisms underlying learning and memory in the mammalian brain. To bridge the gap between learning related behavioral phenomena and their underlying single cell mechanisms, our research combines cellular neurophysiology biochemistry and morphology with behavioral neuroscience. Our data show that odor training results in the following learning-related cellular modifications of intrinsic and synaptic properties in piriform cortex pyramidal neurons:
Our current research is aimed to address four major questions:
1. What are the learning-relevant modifications in inhibitory synaptic transmission, and what are the mechanisms of inducing and maintaining such changes?
2. What is the precise mechanism by which long-lasting enhancement of synaptic transmission is maintained?
3. How is increased neuronal excitability in cortical and hippocampal neurons related to general enhancement in the animals' ability to acquire complex skills?
4. What is the role of metabotropic glutamate receptors in inducing and maintaining learning-relevant neuronal activity?”
Ghosh S, Reuveni I, Lamprecht R, Barkai E.
Persistent CaMKII activation mediates learning-induced long-lasting enhancement of synaptic inhibition. J Neurosci. 2015 Jan 7;35(1):128-39. doi: 10.1523/JNEUROSCI.2123-14.2015
Barkai E. Neural mechanisms of odor rule learning. Prog Brain Res. 2014;208:253-74. doi: 10.1016/B978-0-444-63350-7.00010-3. Review.
Lundi 29 février 2016 à 12h - Emmanuel Pinteaux : " Cerebrovascular inflammation and repair of the blood-brain barrier after stroke"
lieu : Amphithéâtre Margaux Hemingway , Bâtiment IDEE, situé à l'entrée Est du Groupement Hospitalier Est, 59 Bd Pinel (accès boulevard Laurent-Bonnevay) à Bron
invité par Laurent BEZIN (TIGER) et Jean-François GHERSI-EGEA (FLUID)
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Emmanuel Pinteaux PhD, Senior Lecturer, University of Manchester,UK |
Abstract
Inflammation is a key host defence response that contributes to brain damage after ischemic injury, and is associated with poor outcome in stroke patients. Understanding the mechanisms of inflammation is critical for the development of new therapeutic approaches, and is a clinical priority. The inflammatory response after stroke occurs primarily at the blood-brain barrier (BBB), and cerebrovascular inflammation is driven by the cytokine interleukin-1 (IL-1), the action of which leads to a rapid degradation of the extracellular matrix (ECM) of the BBB, activation of endothelial cells and subsequent infiltration of circulating neurotoxic neutrophils into the brain. We have recently demonstrated that this mechanism of cerebrovascular inflammation occurs locally, but also in distant areas from the ischemic core leading to delayed neurodegeneration. We have found that ECM remodelling at the cerebrovasculature induces the generation of bioactive ECM fragments that are key regulators of IL-1-induced endothelial cell activation after cerebral ischaemia. ECM remodelling is regulated by the acute phase protein pentraxin-3 (PTX3), the expression of which is dependent on IL-1 in the injured brain, and we have found that PTX3 is a key mediator of brain repair mechanisms including astrogliosis, BBB repair, brain oedema resolution, angiogenesis and neurogenesis. This presentation will highlight these new mechanisms of neurotoxicity and brain tissue repair that could be targeted for the therapeutic treatment of ischemic stroke.
Thématique de recherche
The research activities of Dr Emmanuel Pinteaux are centered on the role of inflammation in CNS diseases. He developed new genetic mouse models to address the role of Interleukin-1 in cerebrovascular diseases. The presentation will highlight new mechanisms by which the inflammatory response induced by Interleukin-1 contributes to the pathophysiology and the resolution of cerebrovascular diseases such as ischemic stroke. Focus will be put on extracellular matrix remodeling, a field in which Dr Pinteaux is an international leader, and also blood-brain barrier activation and repair, brain edema resolution, angiogenesis and neurogenesis. These new mechanisms of neurotoxicity and brain tissue repair could be targeted for the therapeutic treatment of selected CNS diseases including cerebral ischemia.
1. Abdulaal WH, Walker CR,, Costello R, Mufazalov IA, Papaemmanouil A, Rothwell NJ, Allan SM, Waisman A, Pinteaux E*, Müller W. Characterization of a conditional interleukin-1 receptor 1 mouse mutant using the Cre/LoxP system. Eur J Immunol. Accepted. doi: 10.1002/eji.201546075 (IF 4.0)
2. Bruttger J, Karram K, Wörtge S, Regen T, Marini F, Hoppmann N, Klein M, Blank T, Yona S, Wolf Y, Mack M, Pinteaux E, Müller W, Zipp F, Binder H, Bopp T, Prinz M, Jung S,
Waisman A (2015) Interleukin-1 signaling is involved in local self-renewal and maintenance of microglia. Cell Immunity, 43, 92-106
3. Rodriguez-Grande B, Varghese L, Molina-Holgado F, Rajkovic O, Garlanda C, Denes A, Pinteaux E. (2015) Pentraxin 3 mediates neurogenesis and angiogenesis after cerebral ischaemia. J Neuroinflammation. 24, 12-15
4. Rodriguez-Grande B, Swana M, Nguyen L, Englezou P, Maysami S, Allan SM, Rothwell NJ, Garlanda C, Denes A, Pinteaux E. (2014) The acute-phase protein PTX3 is an essential mediator of glial scar formation and resolution of brain edema after ischemic injury. J Cereb Blood Flow Metab. 34, 480-488
5. Leow-Dyke S, Allen CM, Denes A, Rothwell NJ, Pinteaux E. (2012) Neuronal Toll-like receptor 4 signalling induces brain endothelial activation and neutrophil transmigration in vitro. J. Neuroinflammation 9, 230.
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Invités 2015 Philippe GOFFAUX, 30 mars Michael T HENEKA, 9 avril Denis FOREST, 20 avril JianJun WANG & JingNing ZHU, 11 mai Marie-Germaine Bousser & Lionel Naccache, 9 juin Cendra AGULHON, 21 septembre Niels RATTENBORG, 12 octobre Louise van der WEERD, 9 novembre Nolwen Rey, 14 décembre |
Lundi 14 décembre 2015 à 11h - Nolwen Rey : "Propagation intracérébrale des agrégats de l' alpha-synucléine via le réseau olfactif, et déficits fonctionnels associés dans un modèle murin de maladie de Parkinson"
lieu : Salle de conférence, Bâtiment Inserm, 151 cours A. Thomas, Lyon 3ème
invitée par Anne Didier (NEUROPOP), Luc Zimmer (BIORAN) et Pascale Giraudon (ONCOFLAM-FLUID)
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Nolwen Rey, PhD post-doc, Van Andel Institute, Grand Rapids, Michigan, USA
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Thématique de recherche
Propagation de la synucleinopathie dans le cerveau par mécanisme de type prion.
Plusieurs maladies neurodégénératives sont caractérisées par l’agrégation de l’alpha-synucléine dans le cerveau. Les travaux de Heiko Braak sur les cerveaux post-mortem de patients ayant eu la maladie de Parkinson suggèrent que ces agrégats se propagent via les connections neuronales entre les différentes régions cérébrales affectées, suivant un schéma spatial caractéristique incluant les structures olfactives.
Dans un modèle murin par injection intracérébrale d’alpha-synucléine de forme fibrillaire, nous étudions l’induction, et la propagation des agrégats via les circuits olfactifs, et leurs conséquences fonctionnelles. Nous évaluons également l’effet de différentes conformations de l’alpha-synucléine sur le type de pathologie induite.
Bibliographie brève
. Rey NL, Luk K.C., Trojanowski J.Q.*, Lee V.M.-Y.* and Brundin P. Prion-like spreading of alpha synuclein pathology from the olfactory bulb to central brain regions in mice. In preparation.
. Rey N.L., George S., Brundin P. Spreading the word: precise animal models and validated methods are vital when evaluating prion-like behaviour of alpha-synuclein.
Neuropathology and Applied Neurobiology. Accepted, under revision
. Rey NL., Petit GH., Bousset L., Melki R., Brundin P. Transfer of alpha-synuclein from the olfactory bulb to the brain in mice. Research article. Acta Neuropathologica. Oct 2013. 126(4):555-73.
. Rey NL., Angot E., Dunning C., Steiner JA.*, Brundin P.* Accumulating evidence suggests that Parkinson´s disease is a prion-like disorder. Book chapter in Proteopathic seeds and neurodegenerative diseases, Serie Research and Perspectives in Alzheimer´s disease. March 2013 Ed. Mathias Jucker and Christen Yves. Springer Editions. ISBN 978-3-642- 35491-5
. Rey NL., Sacquet J., Veyrac A., Jourdan F., Didier A. Behavioral and cellular markers of olfactory aging and their response to enrichment. Research article. Neurobiology of aging, March 2012, 33(3):626.e9-626.e23Lundi 9 novembre 2015 à 11h - Louise van der WEERD : "Novel imaging approaches for Alzheimer's Disease"
lieu : Salle de conférence, Bâtiment Inserm, 151 cours A. Thomas, Lyon 3ème
invitée par Fabien Chauveau (BIORAN) et Jean-François GHERSI-EGEA (ONCOFLAM-FLUID)
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Louise van der Weerd PhD, assistant prof., Leiden University Medical Center · Department of Radiology, Molecular Imaging Laboratories Leiden (MILL), Leiden, Netherlands Louise van der Weerd studied Molecular Sciences at Wageningen University (1992-1996), with a Master’s program focussed on MRI and ESR, including an internship at the Commissariat à l'Énergie Atomique (CEA) in Paris. She subsequently obtained a PhD in Biophysics from the same university (2002). This was followed by a postdoc as Research Fellow in the Department of Radiology and Physics at the Institute of Child Health (UCL) in London, where she worked on MRI techniques to study in vivo animal models of neurological disorders. She joined LUMC in 2005 as assistant professor in a double appointment between the department of Radiology and the department of Anatomy to set up a pre-clinical (molecular) imaging program. Presently, she is PI of the molecular imaging section of the MILL. |
Thématique de recherche
Louise van der Weerd works on the development of novel molecular imaging and MRI techniques to study animal models of disease, with a focus on neurological disorders. The research group of Dr. Van der Weerd is embedded in the Molecular Imaging Laboratories Leiden (MILL), a technology platform that combines the available expertise at Leiden University and LUMC necessary for development, validation, and application of molecular imaging techniques. During her presentation, Louise van der Weerd will give an overview of her recent work, with a focus on Alzheimer's disease.
. Rotman M, et al. Enhanced glutathione PEGylated liposomal brain delivery of an anti-amyloid single domain antibody fragment in a mouse model for Alzheimer's disease. J Control Release. 2015 Apr 10;203:40-50.
. Nabuurs RJ, et al. MR microscopy of human amyloid-β deposits: characterization of parenchymal amyloid, diffuse plaques, and vascular amyloid. J Alzheimers Dis. 2013;34(4):1037-49.
Lundi 12 octobre 2015 à 11h - Niels RATTENBORG : Evolution of sleep in mammals and birds: the fruits of comparing apples and oranges
lieu : Salle de conférence, Bâtiment Inserm, 151 cours A. Thomas, Lyon 3ème
Invité par Christelle Peyron (SLEEP), Laurent Seugnet (WAKING), Paul Salin (SLEEP-Forgetting), Perrine Ruby (DYCOG), Hélène Bastuji (NEUROPAIN)
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Niels Rattenborg head of the Avian sleep Research Group at the Max Planck Institute for Ornithology – Seewiesen, Germany. Rattenborg received his undergraduate degree in psychology at Washington University – St. Louis in 1986. After working for 10 years in human sleep medicine clinics, he returned to graduate school and received his PhD on avian sleep from Indiana State University in 1999. Following a post-doc at the University of Wisconsin – Madison, Rattenborg started his independent research group in Seewiesen in 2005. Rattenborg’s group aims to gain insight into the functions of mammalian sleep through studying birds, the only non-mammalian taxonomic group to show unequivocally two sleep states remarkably similar to mammalian slow wave sleep and rapid eye movement (REM) sleep. |
Thématique de recherche
Sleep in birds, and its connections with the constraints of specific ecological situations: flight, migration, reproduction. Sleep and memory consolidation in birds
. Rattenborg NC, Martinez-Gonzalez D. Avian versus mammalian sleep: the fruits of comparing apples and oranges. Current Sleep Medicine Reports, 2014; 1:55-63.
. Beckers GJL, van der Meij J, Lesku JA, Rattenborg NC. Plumes of neuronal activity propagate in three dimensions through the nuclear avian brain. BMC Biology, 2014; 12:16.
. Lesku JA*, Rattenborg NC*, Valcu M*, Vyssotski AL, Kuhn S, Kuemmeth F, Heidrich W, Kempenaers B. Adaptive sleep loss in polygynous pectoral sandpipers. Science, 2012; 337:1654-1658.
. Lesku JA, Vyssotski AL, Martinez-Gonzalez D, Wilzeck C, Rattenborg NC. Local sleep homeostasis in the avian brain: convergence of sleep function in mammals and birds? Proceedings of the Royal Society B: Biological Sciences, 2011; 278:2419-2428.
. Rattenborg NC, Martinez-Gonzalez D. A bird-brain view of episodic memory. Behavioural Brain Research, 2011; 222:236-245.
Lundi 21 septembre 2015 à 11h - Cendra AGULHON : Glia-Glia and Glia-Neuron Interactions in Neurophysiopathology
lieu : Salle de conférence, Bâtiment Inserm, 151 cours A. Thomas, Lyon 3ème
Invitée par Christelle Peyron (SLEEP) ; Pascale Giraudon (ONCOFLAM) et Claire Benetollo (NGFO)
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Cendra Agulhon Chargée de recherche CNRS, Université Paris Descartes |
Thématique de recherche
She is interested in understanding the role of glial cells in the mammalian central nervous system and the mechanisms by which glial cells and neurons interact to support normal communication in the CNS. We are developing and using a set of interdisciplinary and complementary tools and approaches (electrophysiology, DREADD pharmacogenetics, 2-photon Ca2+ imaging, immunohistochemistry, biochemistry, and behavior) to selectively manipulate glial cell signaling and investigate its effects in synaptic transmission and plasticity ex vivo and in vivo in different contexts (during sensory-activated synaptic transmission, development and neurodegenerative diseases).
Bibliographie brève
. Agulhon C, Boyt KM, Xie AX, Friocourt F, Roth BL, McCarthy K. Modulation of the autonomic nervous system by acute glial cell Gq GPCR activation in vivo., J Physiol. 2013, In Press.
. Agulhon C, Sun MY, Murphy T, Myers T, Lauderdale K, Fiacco TA. Calcium signaling and gliotransmission in normal versus reactive astrocytes, Frontiers in Neuropharmacology. Front Pharmacol. 3:139, 2012.
. Agulhon C, Fiacco TA, McCarthy KD , Hippocampal short- and long-term plasticity are not modulated by astrocyte Ca2+ signaling, Science.327:1250-4, 2010.
Mardi 9 juin 2015 à 14h30 -
. Marie-Germaine Bousser : Hémicraniectomie décompressive dans les infarctus cérébraux et dans les thromboses veineuses cérébrales
. Lionel Naccache : Evaluation des troubles de conscience après le coma
lieu : Salle de conférence, Bâtiment Inserm, 151 cours A. Thomas, Lyon 3ème
Invités par Jacques Luauté (IMPACT), Nathalie André-Obadia (PAIN), Fabien Perrin (CAP), Dominique Morlet et Jérémie Mattout (DYCOG)
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Marie-Germaine Bousser Professeur de Neurologie au CHU de Paris, membre de l’académie de médecine et du comité national d’éthique. Avant de prendre sa retraite hospitalière en 2012, elle dirigeait le service de neurologie de l'hôpital Lariboisière. Elle fait partie de l'unité de recherche INSERM U740, spécialisée dans l'étude des maladies génétiques vasculaires cérébrales. Marie-Germaine Bousser est l'auteur de plus de 400 articles scientifiques. Ses travaux, consacrés aux accidents vasculaires cérébraux (AVC) et aux migraines, lui valent une reconnaissance internationale. Avec la généticienne Élisabeth Tournier-Lasserve, elle découvre une maladie génétique, désignée par l'acronyme CADASIL. |
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Lionel Naccache PICNIC Lab : Evaluation physiologique chez les sujets sains et atteints de troubles cognitifs, Institut Cerveau Moëlle, Hôpital de la Pitié-Salpêtrière, Paris. Ancien élève de l’École Normale Supérieure de la rue d'Ulm, Lionel Naccache est professeur de Physiologie à l'université Pierre-et-Marie-Curie Paris 6. Il est neurologue et neurophysiologiste à l'hôpital de la Pitié-Salpêtrière et exerce une activité de chercheur en neurosciences cognitives à l'Institut du cerveau et de la moelle épinière (ICM) à Paris1. Il consacre ses travaux à l'exploration des propriétés psychologiques et cérébrales de la conscience. Il est membre du Comité national d'éthique. |
Bibliographie brève
. Faugeras F, Rohaut B, Weiss N, Bekinschtein T, Galanaud D, Puybasset L, Bolgert F, Sergent C, Cohen L, Dehaene S, Naccache L
Event related potentials elicited by violations of auditory regularities in patients with impaired consciousness.
Neuropsychologia 2012
. Imen El Karoui, Jean-Remi King, Jacobo Sitt, Florent Meyniel, Simon Van Gaal, Dominique Hasboun, Claude Adam, Vincent Navarro, Michel Baulac, Stanislas Dehaene, Laurent Cohen, and Lionel Naccache. Event-Related Potential, Time-frequency, and Functional Connectivity Facets of Local and Global Auditory Novelty Processing: An Intracranial Study in Humans. Cereb Cortex, June 2014
. Kurth T, Chabriat H, Bousser MG.Migraine and stroke: a complex association with clinical implications. Lancet Neurol. 2012 Jan;11(1):92-100.
. Théaudin M, Crassard I, Bresson D, Saliou G, Favrole P, Vahedi K, Denier C, Bousser MG. Should decompressive surgery be performed in malignant cerebral venous thrombosis?: a series of 12 patients. Stroke. 2010 Apr;41(4):727-31.
Lundi 11 mai 2015 à 11h -
Jian Jun WANG : Role of orexin in central vestibular motor control and cataplexy
Jinf Ning ZHU : Hypothalamic histaminergic modulation on cerebellar motor control
lieu : Salle de conférence, Bâtiment Inserm, 151 cours A. Thomas, Lyon 3ème
Invités par Tao Jiang (CMO), Jian Shen Lin (WAKING), Denis Pélisson (IMPACT)
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Jian Jun Wang Professor and Director of Physiology & Neurobiology, School of Life Sciences, Nanjing University, China. |
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Jing Ning Zhu |
Thématique de recherche
Prof Wang : Research interest is neurobiology of the central motor system and focused on the functional significances of neural circuits between the hypothalamus and motor structures. Current studies : include hypothalamic histaminergic and orexinergic modulation on motor control via the cerebellum, basal ganglia and vestibular nuclei, and interactions between central motor structures and hypothalamus. Mécanismes et fonction des twitches musculaires pendant le sommeil paradoxal et au cours du développement. Il fait intervenir des notions concernant le contrôle moteur, les systèmes réflexes et la perception neurosensorielle pendant le sommeil et ceci au cours du développement.
Bibliographie brève
. Jun Zhang, Bin Li, Lei Yu, Hong-Zhao Li, Jing-Ning Zhu*, Jian-Jun Wang*: A role for orexin in central vestibular motor control. Neuron, 69:793-804, 2011.
. Qian-Xing Zhuang, Yong-Hui Wu, Guan-Yi Wu, Jing-Ning Zhu*, Jian-Jun Wang*: Histamine excites rat superior vestibular nuclear neurons via postsynaptic H1 and H2 receptors in vitro. NeuroSignals, 21:174-183, 2013.
Lundi 20 avril 2015 à 11h - Denis FOREST : Neuroscepticisme : épistémologie des neurosciences.
lieu : Salle de conférence, Bâtiment Inserm, 151 cours A. Thomas, Lyon 3ème
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Denis Forest Philosophe Professeur des Universités, Directeur de l'Institut de Recherches Philosophiques, Directeur de l'Ecode Doctorale 139 "Connaissance, langage, modélisation" |
Bibliographie
2014, Neuroscepticisme. Les sciences du cerveau sous le scalpel de l'épistémologue, Paris, Editions d'Ithaque. 208 pages.
Lien vers la vidéo de Présentation: http://youtu.be/3usKUsiypk4
Jeudi 9 avril 2015 à 11h - Michael T HENEKA : Does innate immune activation contribute to Alzheimer’s disease?
lieu : Salle des thèses - Faculté Laennec - rue G. Parradin à Lyon
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Michael T Heneka is a Professor in Neurology at the Neurological Clinic of the University of Bonn, Germany. He is the head of the Clinical Neuroscience Unit, a neuroscience laboratory in the Department of Neurology at the University of Bonn. The focus of his work are the molecular mechanisms of neurodegeneration and its translation into clinical application. |
Bibliographie
. Heneka MT, Carson MJ, Khoury JE, et al . Neuroinflammation in Alzheimer's disease. Lancet Neurol, 2015, 14(4): 388-405.
. Heneka MT, Golenbock DT, Latz E. Innate immunity in Alzheimer's disease. Nat Immunol, 2015, 16(3): 229-236.
. Krauthausen M, Kummer MP, Zimmermann J, Reyes-Irisarri E, Terwel D, Bulic B, Heneka MT, Muller M. CXCR3 promotes plaque formation and behavioral deficits in an Alzheimer's disease model. J Clin Invest, 2015, 125(1): 365-378.
. Heneka MT. Macrophages derived from infiltrating monocytes mediate autoimmune myelin destruction. J Exp Med, 2014, 211(8): 1500.
. Heneka MT, Kummer MP, Latz E. Innate immune activation in neurodegenerative disease. Nat Rev Immunol, 2014, 14(7): 463-477.
. Gaikwad SM, Heneka MT. Studying M1 and M2 states in adult microglia. Methods Mol Biol, 2013, 1041: 185-197.
. Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature, 2013, 493(7434): 674-678.
Full list of publications
http://www.ncbi.nlm.nih.gov/pubmed/?term=Heneka+MT
Lundi 30 mars 2015 à 11h - Philippe GOFFAUX : Douleur en tête: La réponse extraordinaire d'une expérience ordinaire.
lieu : Salle de conférence, Bâtiment Inserm, 151 cours A. Thomas, Lyon 3ème
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Philippe Goffaux Professeur agrégé, Faculté de Médecine, Université de Sherbroke, Québec, Canada“My research interests are in the field of pain and electrophysiology. I am particularly interested in studying the interface between psychological processes and human biology, charting the impact of pre-existing vulnerabilities as potential risk factors for the development of chronic pain syndromes” |
Abstract
La douleur est un phénomène sensoriel qui dépend autant de l'intensité des signaux nociceptifs, que de notre capacité à moduler ces signaux. Hormis la présence de systèmes médullaires pleinement efficaces permettant de faire taire l'influx nociceptif avant son ascension vers le cerveau (e.g., modulation homosegmentaire), il existe des systèmes supra-spinaux interconnectés qui permettent à l'homme de vivre toute une gamme d'expériences douloureuses. Ces systèmes supra-spinaux sont complexes et commencent à peine être déchiffrés. Dans mon laboratoire, on s'est intéressé à comprendre la neurophysiologie de l'effet placebo et les attentes en générales (attentes d'analgésie et/ou d'hyperalgésie). On s'est aussi intéressé à la différence homme-femme dans le traitement cérébral de l'information nociceptive et dans l'activation des circuits liés à la perception du danger ("threat control circuits"). Mes découvertes se sont surtout faites grâce à l'enregistrement électroencéphalographique - qui procure une excellente résolution temporelle et qui permet donc de savoir quand le cerveau réagit à une stimulation douloureuse. Ultimement mes travaux ont pour but d'aider l'homme à maitriser sa douleur et à prévenir sa chronicisation. Mes plus récents travaux vont dans ce sens puisque je mène présentement des recherches sur la mémoire de la douleur et sur son rôle dans le phénomène de chronicisation. Fait intéressant, une revue systématique récemment publiée dans JAMA1 confirme trois choses en ce qui concerne le développent de la douleur chronique : (1) il existe peu de facteurs cliniques associés clairement à la chronicisation de la douleur chez l'homme; (2) la majorité des facteurs prédictifs identifiés jusqu'à ce jour sont d'ordre psychologique et n'expliquent que peu de la variance attribuable à la chronicisation de la douleur; et (3) il n'existe aucune étude ayant développé des algorithmes de traitement basés sur l'arrimage des données cliniques et expérimentales. Pourtant, des données expérimentales récentes dans le domaine de la douleur montrent que la chronicisation de la douleur chez l'humain passe par une modification (i.e., plasticité) du système nerveux central. Peut-on vraiment se permettre d'ignorer encore longtemps la "douleur en tête"?
Bibliographie
. Parent, A., Beaudet, N., Daigle, K., Sabbagh, R., Sansoucy, Y., Marchand, S., Sarret, P., Goffaux, P*. (in press). Relationship between blood-and CSF-bound neurotransmitter concentrations and conditioned pain modulation in pain-free and chronic pain subjects. The Journal of Pain,
. Girard-Tremblay, L., Auclair, V., Daigle, K., Léonard, G., Whittingstall, K., Goffaux P.* (2014). Sex differences in the neural representation of pain unpleasantness. The Journal of Pain, 15(8), 867–877.
. Nugent, S., Castellano, CA., Goffaux, P., Whittingstall, K., Lepage, M., Paquet, N., Bocti, C., Fulop, T., Cunnane, SC. (2014).Glucose hypometabolism is highly localized but lower cortical thickness and brain atrophy are widespread in cognitively normal older adults. American journal of physiology. Endocrinology and metabolism, 306, E1315–E1321,
. Chalaye, P., Lafrenaye, S., Goffaux, P., Marchand, S. (2014). The role of cardiovascular activity in fibromyalgia and conditioned pain modulation. Pain, 155(6), 1064–1069.
. Goffaux, P.*, Girard-Tremblay, L., Marchand, S., Daigle, K., Whittingstall, K. (2013). Individual differences in pain sensitivity vary as a function of precuneus reactivity. Brain topography, 27(3), 366-374.
. Daigle, K., Fortin, D., Mathieu, D., Saint-Pierre, AB., Paré, FM., de la Sablonnière, A., Goffaux, P.* (2013). Effects of surgical resection on the evolution of quality of life in newly diagnosed patients with glioblastoma: a report on 19 patients surviving to follow-up. Current medical research and opinion, 29(10), 1307-1313
. Goffaux, P.*, Léonard, G., Lévesque, M. (2013). Perception de la douleur en santé mentale. Marchand, S., Saravane, D., Gaumond, I. (Eds.). Santé mentale et douleur.
. Lévesque, M., Potvin, S., Marchand, S., Stip, E., Grignon, S., Lalonde, P., Lipp, O., Goffaux, P.* (2012). Pain perception in schizophrenia: Evidence of a specific pain response profile. Pain Medicine, 13, 1571-9, [IF=2.537].
. Leonard, G., Lafrenaye, S., Goffaux, P.* (2012). Randomized placebo-controlled cross-over designs in clinical trials: A gold-standard to be re-assessed. Current medical research and opinion, 28, 1-4.
. Chalaye, P., Goffaux, P., Bourgault, P., Lafrenaye, S., Devroede, G., Watier, A., Marchand, S. (2012). Comparing pain modulation and autonomic responses in fibromyalgia and irritable bowel syndrome patients. Clinical Journal of Pain, 28, 519-26, [IF=3.114].
. Goffaux, P.*, Daigle, K., Fortin, D. (2011). Patients with Brain Cancer: Health Related Quality of Life. In Hayat, M.A. (Ed.). Tumors of the Central Nervous System, Volume 4 - Brain Tumors (Part 2).
. Fortin, D., Goffaux, P. (2011). Headaches in Patient with Brain Tumors. In Hayat, M.A. (Ed.). Tumors of the Central Nervous System, Volume 4 - Brain Tumors (Part 2).
. Goffaux, P.*, Leonard, G., Marchand, S. (2011). Pain processing in the cingulate cortex: behavioral studies in humans. In Schmidt, R.F. & Willis, W.D. (Eds.), Encyclopedic Reference of Pain, 2nd, Edition, Springer-Verlag (Publishers).
. Goffaux, P.*, Michaud, K., Gaudreau, J., Chalaye, P., Rainville, P., Marchand, S. (2011). Sex differences in perceived pain are affected by an anxious brain. Pain. 152, 2065-73.
. Stock, C., Teyssier, G., Pichot, V., Goffaux, P., Barthelemy, J.- C., Patural, H. (2010). Autonomic dysfunction with early respiratory syncytial virus-related infection. Autonomic neuroscience, 156, 90-95.
. Goffaux, P.*, Fortin, D. (2010). Brain tumor headaches: From bedside to bench. Neurosurgery, 67, 459-466.
. Goffaux, P. *, Léonard, G., Rainville, P., Marchand, S. (2010). Placebo Effects: From Context to Anatomy. In P. Beaulieu (Ed.). Pharmacology of Pain.
. Leonard, G., Goffaux, P., Marchand, S. (2010). Deciphering the role of endogenous opioids in high frequency TENS using small and high doses of naloxone. Pain, 151, 215-219.
. Goffaux, P., Barcellos de Souza, J., Potvin, S., P., Marchand, S. (2009). Pain relief through expectation supersedes descending inhibitory deficits in fibromyalgia patients. Pain, 145, 18-23.
. Léonard, G., Goffaux, P., Mathieu, D., Kenny, B., Blanchard, J., Marchand, S., (2010) Evidence of descending inhibition deficits in atypical but not classical trigeminal neuralgia. Pain, 147, 217-23.
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Invités 2014 Jens P. Dreier, 27 janvier Pascal Derkinderen, 3 avril Clément Léna, 28 avril Mikko Sams, 2 juin Grédor Thut, 16 juin Marcos G. Frank, 15 septembre Mark Blumberg, 24 novembre |
Lundi 24 novembre 2014 à 11h - Mark Blumberg : Mapping the sensorimotor system in our sleep
lieu : Salle de conférence, Bâtiment Inserm, 151 cours A. Thomas, Lyon 3ème
Invité par Christelle Peyron (SLEEP), J.S. Lin (WAKING), Perrine Ruby (DYCOG)
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Mark Blumberg Professor Departments of Psychology and Biology E11 Seashore Hall University of Iowa Iowa City, Iowa 52242 http://psychology.uiowa.edu/blumberg-lab |
Thématique de recherche
Mécanismes et fonction des twitches musculaires pendant le sommeil paradoxal et au cours du développement. Il fait intervenir des notions concernant le contrôle moteur, les systèmes réflexes et la perception neurosensorielle pendant le sommeil et ceci au cours du développement.
Bibliographie brève
. Tiriac A, Del Rio-Bermudez C, Blumberg MS. Self-Generated Movements with "Unexpected" Sensory Consequences. Curr Biol. 2014 Aug 12. pii: S0960-9822(14)00916-6. doi: 10.1016/j.cub.2014.07.053. [Epub ahead of print]
. Blumberg MS, Coleman CM, Gerth AI, McMurray B. Spatiotemporal structure of REM sleep twitching reveals developmental origins of motor synergies. Curr Biol. 2013 Nov 4;23(21):2100-9.
lundi 15 septembre 2014 à 11h - Marcos G. Frank : Sleep to weaken, sleep to strengthen: An integrative view of sleep and synaptic plasticity
lieu : Salle de conférence, Bâtiment Inserm, 151 cours A. Thomas, Lyon 3ème
Cette conférence sera suivie de la journée "datablitz sommeil" : en savoir+
Proposition de Laurent Seugnet (WAIKING), Christelle Peyron et Paul Salin (SLEEP), Hélène Bastuji (PAIN), Perrine Ruby (DYCOG)
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Marcos G. Frank PhD, Associate Professor of Neuroscience, University of Pennsylvania, School of Medicine, |
Thématique de recherche
Marcos Frank received his PhD in Neuroscience at Stanford University in 1997, where he worked in the laboratory of H. Craig Heller studying the ontogenesis of sleep and sleep regulation in rodents. This line of research provided new insights into sleep homeostasis in infancy and how this and related processes are altered by fetal exposure to psychoactive compounds. He then conducted post-doctoral research in the laboratory of Michael P. Stryker at the University of California, San Francisco demonstrating a role for sleep in a canonical form of in vivo cortical synaptic plasticity, originally described by David Hubel and Torsten Wiesel. He has continued this line of research as an Associate Professor at the University of Pennsylvania since 2003. Among other discoveries, the Frank lab has shown that sleep is associated with the activation of glutamate receptors and enzymatic pathways that consolidate experience-dependent plasticity in the cortex. A second line of research is focused on the role of glial astrocytes in sleep regulation. In collaboration with Dr.’s Phil Haydon and Ted Abel, Dr. Frank and his colleagues showed that astrocytic gliotransmission (i.e. the release of neurotransmitters by astrocytes) plays an important role in sleep homeostasis. Both research topics are active areas of investigation in the Frank laboratory, and work along these lines has appeared in the Journals Neuron, Current Biology, Proceedings of the National Academy of Sciences, Journal of Neuroscience and SLEEP. Dr. Frank is also the author of several review articles and book chapters on the topics of glial regulation of sleep, sleep function and the role of sleep in brain plasticity, and is the senior editor of Current Advances in Sleep Biology (Nova Biomedical Books, 2009) and Brain Activity in Sleep (Elsevier, 2012).
Bibliographie brève
. Frank, M.G., Issa, N.P. and Stryker, M.P.: Sleep enhances plasticity in developing visual cortex. Neuron 30: 275-287, 2001.
. Jha, S.K., Jones, B.E., Coleman, T., Steinmetz, N., Law, C.T., Griffin, G., Hawk, J., Dabbish, N., Kalatsky, V.A. and Frank, M.G.: Sleep-dependent plasticity requires cortical activity. Journal of Neuroscience 25(40): 9266-9274, August 2005.
. Hallasa M, Florian C, Fellin T, Munoz JR, Abel T, Haydon P, and Frank MG: Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss. Neuron 61(2): 213-219, January 29 2009.
.Aton S, Seibt J, Dumoulin M, Jha SK, Steinmetz N, Coleman T, Naidoo N, Frank MG: Mechanisms of sleep-dependent consolidation of cortical plasticity. Neuron 61(3): 454-466, February 12 2009.
lundi 16 juin 2014 à 11h - Grégor Thut : Neuronal state-dependency of visual perception/Effet des fluctuations de l'activité neuronale sur la perception visuelle
lieu : Salle de conférence, Bâtiment Inserm, 151 cours A. Thomas, Lyon 3ème
Proposition de Laure Pisella, Karen Reilly, Denis Pélisson, Alessandro Farnè (IMPACT)
Karim Jerbi, Jérémie Mattout, Anne Caclin Olivier Bertrand (DYCOG)
Luis Garcia-Larrea (NEUROPAIN)
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Grégor Thut Professor, Institute of Neuroscience and Psychology, University of Glasgow http://www.gla.ac.uk/researchinstitutes/neurosciencepsychology/staff/gregorthut/ |
Thématique de recherche
G, Thut research focuses on neuronal state-dependency of visual perception. By combining TMS, careful behavioral measures, and other complementary techniques (such as EEG) in a multimodal neuroimaging approach, he studies the mechanisms that lead to changes in the visual brain conditioning where (spatial biases), when (speed) and whether (awareness) an upcoming visual stimulus will be perceived. He is particularly interested in how visual cortex excitability/activity can be modulated in the absence of retinal input through (1) voluntary control (attention research), (2) spontaneous fluctuations (research on resting state activity), (3) crossmodal sensory input (multisensory research) or (4) direct brain stimulation (neuromodulation via TMS) to bias perception in specific directions. He explore the functional role of brain rhythms (oscillatory brain activity)
Bibliographie brève
. Benwell, C.S.Y., Harvey, M., Gardner, S., and Thut, G. (2013) Stimulus- and state-dependence of systematic bias in spatial attention: Additive effects of stimulus-size and time-on-task.Cortex, 49 (3). pp. 827-836.
. Romei, V., Murray, M.M., Cappe, C., and Thut, G. (2013) The contributions of sensory dominance and attentional bias to cross-modal enhancement of visual cortex excitability.Journal of Cognitive Neuroscience, 25 (7). pp. 1122-1135.
lundi 2 juin 2014 à 11h - Mikko Sams : Studying brain under naturalistic conditions/Etudier le cerveau en situation naturelle
lieu : Salle de conférence, Bâtiment Inserm, 151 cours A. Thomas, Lyon 3ème
invité par l'équipe IMPACT et DYCOG
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Mikko Sams Professor, School of Science, Aalto University, P.O.Box 12200, FI-00076 Aalto, Finland Brain and Mind Laboratory Dept. of Biomedical Engineering and Computational Science, http://becs.aalto.fi/en/personnel/staff/sams_mikko.html |
Abstract
We are increasingly studying human brain activity under conditions resembling real life. As methods, we have used inter-subject correlations1,3 and multi-voxel pattern analysis of fMRI signals. Using these relatively new methods, we have examined neural basis of, e.g., emotions and perspective taking2,6.
Our results suggest that experiencing similar emotions increases synchrony of subjects watching emotional movie clips2. Negative valence was associated with increased ISC in the emotion-processing network and in the default-mode network. High arousal was associated with increased ISC in the somatosensory cortices and visual and dorsal attention networks.
In another study, we studied how taking a perspective of a loosing or winning boxer is reflected in the brain6. During passive viewing, subjects’ brain activity was synchronized in sensory projection and posterior temporal cortices. Simulation induced widespread increase of synchrony in the Action Observation Network the dorsal attention circuits.
In the third study4 we showed that when individuals adopt a similar psychological perspective during natural viewing, their brain activity becomes synchronized in specific brain regions. Synchronization was not explained by differences in visual sampling of the movies, as estimated by eye gaze. We proposed that synchronous brain activity across individuals adopting similar psychological perspectives could be an important neural mechanism supporting shared understanding of the environment.
Multifaceted and idiosyncratic aberrancies in social cognition characterize autism spectrum disorders (ASDs). We measured fMRI in individuals with ASD and matched-pair neurotypical (NT) controls while they were viewing a feature film portraying social interactions5. Individuals with ASD showed lower ISC than NT controls in brain regions implicated in processing social information including the insula, posterior and anterior cingulate cortex, caudate nucleus, precuneus, lateral occipital cortex, and supramarginal gyrus. Results suggest that the minds of ASD individuals do not ‘tick together’ with others while perceiving identical dynamic social interactions
Bibliographie
- Kauppi, J-P., Jääskeläinen, I.P. Sams, M. and Tohka, J. Inter-Subject Synchronization of Brain Hemodynamic Responses During Watching a Movie: Localization in Space, Time, and Frequency. Frontiers in Neuroinformatics, 2010, 4:5. doi:10.3389/fninf.2010.00005.
- Nummenmaa, L., Glerean, E., Viinikainen, M., Jääskeläinen, I.P., Hari, R. and Sams, M. Emotional contagion may promote social interaction by synchronizing brain activity across individuals. Proc. Natl. Acad. Sci. U S A. 2012, 109, 24, 9599-9604.
- Glerean, E. Salmi., J., Lahnakoski., J., Jääskeläinen., I.P. and Sams, M. FMRI phase synchronization as a measure of dynamic functional connectivity. Brain Connectivity, 2012, 2, 91-101.
- Lahnakoski, J.M., Glerean, E., Jääskeläinen, I.P., Hyönä, J., Hari, R., Sams, M., and Nummenmaa, L. Synchronous brain activity across individuals underlies shared psychological perspectives. Revision submitted.
- Salmi, J., Roine, U., Glerean, E., Lahnakoski, J., Nieminen-von Wendt, T, Tani, P., Leppämäki, S., Nummenmaa, L., Carlson, S. Jääskeläinen, I.P., Rintahaka, P. and Sams, M. The brains of high functioning autistic individuals do not synchronize with those of others. NeuroImage Clinical, 2013, 3, 489-497.
- Nummenmaa, L., Smirnov, D., Lahnakoski, J., Glerean, E., Jääskeläinen, I.P., Sams, M. and Hari. R. Mental Action Simulation Synchronizes Action-Observation Circuits Across Individuals. J. Neuroscience, 2014, 34, 748-757.
lundi 28 avril 2014 à 11h - Clément Léna : Le dialogue entre cervelet et cortex cérébral dans l'exploration sensorielle active/Cerebellum and cerebral cortex dialogue in active sensory exploration.
lieu : Salle de conférence, Bâtiment Inserm, 151 cours A. Thomas, Lyon 3ème
Proposition de Nathalie Buonviso (CMO), Olivier Bertrand (DYCOG), Denis Pélisson (IMPACT), Pierre-Hervé Luppi (SLEEP) et Olivier Pascual (ONCOFLAM)
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Clément Léna DR2 INSERM, chercheur à l'ENS Paris, Département de Biologie 5, rue d'Ulm, 75230 Paris cedex 5 |
Thématique de recherche
Cervelet, oscillations et anatomie fonctionnelle des boucles cérébello-corticales dans le comportement d'exploration ; approches méthodologiques (optogénétique, imagerie anat et fonctionnelle, tractographie par virus, électrophy, oscillations, pharmaco ...)
Abstract
The cerebellum has long been known to receive from and project to the cortex. However, the topography of these reciprocal connections have been, until recently, eluded to a proper mapping and thus targeted manipulations. We investigated this topic in rodents using the whisker system as a model of sensori-motor function. We demonstrated, by a combination of multiple tools, the existence of closed loops between the sensori-motor cortices and the cerebellar cortex, and showed the importance of these loops for the fine motor adjustments that take place in active sensory exploration of the environment.
Bibliographie brève
. Popa D, Spolidoro M, Proville RD, Guyon N, Belliveau L, Léna C. Functional role of the cerebellum in gamma-band synchronization of the sensory and motor cortices. J Neurosci. 2013 Apr 10;33(15):6552-6.
. de Solages C, Szapiro G, Brunel N, Hakim V, Isope P, Buisseret P, Rousseau C, Barbour B, Léna C. High-frequency organization and synchrony of activity in the purkinje cell layer of the cerebellum. Neuron. 2008 Jun 12;58(5):775-88.
Jeudi 3 avril 2014 à 11h - Pascal Derkinderen : Tube digestif et maladie de Parkinson: le vrai, le faux et le possible.
lieu : Salle de conférence, Bâtiment Inserm, 151 cours A. Thomas, Lyon 3ème
Proposition de Fabien Chauveau, Luc Zimmer (BIORAN) et Laurent Bezin (TIGER)
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Pascal Derkinderen Pascal Derkinderen earned his MD in neurology and PhD in molecular and cellular neuropharmacology from Paris 6 University in 1997 and 1999, respectively. As a postdoc in Brian Anderton’s laboratory at the Institute of Psychiatry in London UK, he studied the regulation of the tyrosine phosphorylation of the microtubule associated protein tau and identified a new tau kinase. He is currently professor of Neurology at Nantes University, France, where he is leading in Michel Neunlist’s lab (Inserm U913) a small research team devoted to the study of the enteric nervous system in Parkinson’s disease. |
Thématique de recherche
Pascal Derkinderen is specialized in neurodegenerative disorders. Back from London in 2006, he started collaboration with Michel Neunlist on the enteric nervous system in Parkinson’s disease.
His research team demonstrated that the enteric nervous system can be readily analyzed using routine colonic biopsies.
This led them to propose that the enteric nervous system could represent a unique window to assess the neuropathology in living patients with neurodegenerative disorders (Derkinderen et al., Neurology 2011). Their current research focuses on
the development of enteric biomarkers for Parkinson’s disease and related disorders.
Abstract
Le tube digestif concentre en son sein l‘ensemble des cellules du corps humain, et il héberge dans sa lumière un nombre important de bactéries. L’ensemble des fonctions digestives est assuré par un véritable deuxième cerveau (le système nerveux entérique ; SNE) faisant du tube digestif le deuxième organe neurologique de notre corps. L'équipe du Pr Derkinderen a mis au point une méthode originale d'analyse de biopsies du côlon chez des patients parkinsoniens permettant une évaluation neuropathologique du vivant du patient. Ainsi de nouveaux biomarqueurs entériques sont proposés pour l’étude des synucléinopathies.
. Derkinderen P, Rouaud T, Lebouvier T, Bruley des Varannes S, Neunlist M, De Giorgio R. Parkinson disease: the enteric nervous system spills its guts. Neurology. 2011 Nov 8;77(19):1761–7.
. Neunlist M, Van Landeghem L, Mahé MM, Derkinderen P, des Varannes SB, Rolli-Derkinderen M. The digestive neuronal–glial–epithelial unit: a new actor in gut health and disease. Nat Rev Gastroenterol Hepatol. 2013 Feb;10(2):90–100.
Lundi 27 janvier 2014 à 11h - Jens P. Dreier : The relationship between spreading depolarization and ictal epileptic activity/Relation entre ondes de dépolarisation et activité épileptique.
lieu : Hôpital neurologique - amphi du 6ème étage - accès ascenseur via Entrée B - Groupement Hospitalier Est - 59 bd Pinel à Bron
Proposition de Stéphane Marinesco (Neurochem, WAKING), Anne Meiller (Neurochem), Laurent Bezin et Thomas Lieutaud (TIGER), Baptiste Balanca (WAKING), Luc Zimmer et Armand Perret-Laudet (BIORAN)
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Jens P. Dreier Charité - Universitätsmedizin Berlin (Medical Faculty) - Team Leader. The Center for Stroke Research Berlin (CSB) at the Charité - Universitätsmedizin Berlin has been funded since July 2008 by the Federal Ministry of Education and Research as an Integrated Research and Treatment Center (IFB). http://www.schlaganfallcentrum.de/index.php?id=221 |
Thématique de recherche
Jens Dreier est la référence mondiale pour les CSD (cortical spreading depolarization), auteurs des meilleures publications du domaine et membre fondateur du groupe international COSBID (cooperative group for the study of brain injury depolarizations).
Abstract
In the evolution of the cerebral cortex, the sophisticated organization in a steady state far away from thermodynamic equilibrium has produced the side effect of two fundamental pathological network events: ictal epileptic activity and spreading depolarization. Ictal epileptic activity describes the partial disruption, and spreading depolarization describes the near-complete disruption of the physiological double Gibbs–Donnan steady state. The occurrence of ictal epileptic activity in patients has been known for decades. Recently, unequivocal electrophysiological evidence has been found in patients that spreading depolarizations occur abundantly in stroke and brain trauma. The ion changes can be taken to estimate relative changes in Gibbs free energy from state to state. The calculations suggest that in transitions from the physiological state to ictal epileptic activity to spreading depolarization to death, the cortex releases Gibbs free energy in a stepwise fashion. Spreading depolarization thus appears as a twilight state close to death. Consistently, electrocorticographic recordings in the core of focal ischemia or after cardiac arrest display a smooth transition from the initial spreading depolarization component to the later ultraslow negative potential, which is assumed to reflect processes in cellular death.
. Drenckhahn, C., Winkler, M.K.L., Major, S., Scheel, M., Kang, E.J., Pinczolits, A., Grozea, C., Hartings, J.A., Woitzik, J., Dreier, J.P., COSBID study group:
Correlates of spreading depolarization in human scalp electroencephalography. Brain. 2012; 135:853-68.
. Dreier, JP. The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease. Nat Med. 2011;1 7:439-47.
Lundi 4 novembre 2013 à 11h - Jan BORN : Learning during sleep - not a dream.
Salle de conférence, Bâtiment Inserm, 151 cours A. Thomas, Lyon 3ème
Proposition de Pierre-Hervé Luppi et Gaël Malleret (SLEEP), JianSheng Lin et Laurent Seugnet (WAKING), Nadine Ravel (CMO).
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Jan BORN Jan Born is director of the Department of Medical Psychology and Behavioral Neurobiology at the University of Tübingen, Germany. He obtained Ph.D.s in Psychology and Physiology. After stays as research fellow in the Department of Biological Psychology at the State University of New York at Stony Brook and as a post doc at the Department of Physiology at the University of Ulm, Germany, he was appointed full professor of Physiological Psychology at the University of Bamberg in 1989. In 1999, he joined the Department of Neuroendocrinology at the University of Lübeck, and changed in 2010 to his current position. Dr. Born's primary research interests are in the dynamics of memory formation in biological systems. He is particularly interested in the memory functions that sleep serves for the central nervous system, metabolic system and the immune system. He is speaker of the collaborative research center "Plasticity and Sleep", founded in 2005 by the German Science Foundation at the Universities of Lübeck and Kiel, Germany. In 2010 he received the Leibniz award of the German Science Foundation. He has co-authored more than 300 publications. |
Thématique de recherche
How are memories consolidated during sleep ? What are the neuropsychological and neurophysiological determinants of food intake in humans ?
Methods : Behavioual tests, electrophysiological activity (LFP, EEG, MEG), endocrine and immunological measures (hormones assays, FACS, etc) in human and rats.
Bibliographie brève
. Diekelmann S, Born J (2010). The memory function of sleep. Nature Rev Neurosci. 11(2):114-26.·
. Rasch B, Pommer J, Diekelmann S, Born J. (2009) Pharmacological REM sleep suppression paradoxically improves rather than impairs skill memory. Nature Neurosci 12: 396-7
. Rasch B, Büchel C, Gais S, Born J. (2007) Odor cues during slow wave sleep prompt declarative memory consolidation. Science 315: 1426-1429
. Diekelmann S, Born J. (2007) One memory, two ways to consolidate? Nature Neurosci 10: 1085-1086
. Marshall L, Born J. (2007) The contribution of sleep to hippocampus-dependent memory consolidation. Trends Cogn Sci. 11:442-450
Lundi 14 octobre 2013 à 11h - Hans Peter LANDOLT : What keeps the brain awake? The human pharmaco-genetics of CNS stimulants.
Salle de conférence, Bâtiment Inserm, 151 cours A. Thomas, Lyon 3ème
Proposition de Laurent Seugnet (WAKING), christelle Peyron (SLEEP), Hélène Bastuji (NEUROPAIN), Perrine Ruby (DYCOG).
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Hans Peter LANDOLT Neural Basis of Behavior - Institute of Pharmacology & Toxicology University of Zurich - Winterthurerstrasse 190 - 8057 Zurich Fascinated by integrative, translational biomedical science, my research strives to enhance our understanding of a basic physiological process, such as the sleep-wake cycle, for health and disease. I obtained a PhD in Natural Sciences from the ETH Zürich (1996), and conducted postdoctoral fellowships at the University of Zürich (1996-1997) and the University of California in San Diego (UCSD) (1998-2000). Upon completion of a 3-year Fellowship in Clinical Psychopharmacological Research at UCSD, I joined in 2001 the Institute of Pharmacology and Toxicology of the University of Zürich as group leader and senior scientist. I developed and currently lead an independent research program, which employs state-of-the-art methods of system neurophysiology, neuro-psychopharmacology, human genetics, molecular brain imaging and neuro¬cognitive testing to investigate the roles for neuromodulators and neurotransmitters in regulating sleep-associated brain functions. |
Thématique de recherche
"Major aspects of sleep-wake regulation are genetically controlled. We are interested in genotype-dependent differences in sleep, waking performance and response to sleep- and wake-promoting pharmacological agents. To elucidate molecular mechanisms of sleep-wake regulation in health and disease, we combine and integrate methods of human genetics, selective pharmacology, multi-channel EEG, neuropsychological/cognitive testing and brain imaging.”
Bibliographie brève
. Hefti K, Holst SC, Sovago J, Bachmann V, Buck A, Ametamey SM, Scheidegger M, Berthold T, Gomez-Mancilla B, Seifritz E, Landolt HP. Increased Metabotropic Glutamate Receptor Subtype 5 Availability in Human Brain After One Night Without Sleep. Biol Psychiatry. 2012 Sep 6.
. Landolt HP. "No thanks, coffee keeps me awake": individual caffeine sensitivity depends on ADORA2A genotype. Sleep. 2012 Jul 1;35(7):899-900.
. Landolt HP, Rétey JV, Adam M. Reduced neurobehavioral impairment from sleep deprivation in older adults: contribution of adenosinergic mechanisms. Front Neurol. 2012;3:62. Epub 2012 Apr 27.
Lundi 23 septembre 2013 à 11h - Donald A. WILSON : Learning to smell
Salle de conférence, Bâtiment Inserm, 151 cours A. Thomas, Lyon 3ème
Proposition d'Anne-Marie Mouly et des équipes NEUROPOP et CMO
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Donald A. WILSON Research Professor, Child and Adolescent Psychiatry New York University School of Medicine Senior Research Scientist, Emotional Brain Institute Nathan Kline Institute for Psychiatric ResearchAffiliated Professor, Department of Zoology, University of Oklahoma. Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research Orangeburg, NY 10962, USA http://faculty-staff.ou.edu/W/Donald.A.Wilson-1/ |
Thématiques de recherche
The laboratory of Donald Wilson, PhD (a research scientist at NKI and a Research Professor of Child and Adolescent Psychiatry at the NYU/Langone School of Medicine) focuses on perceptual learning, sensory gating, object coding, and hedonic coding in the mammalian olfactory system.
Perception of odors involves a synthesis of often hundreds of molecular features into perceptual objects, similar to visual object recognition. Interestingly, in olfaction this process occurs primarily not in a neocortical architecture, but rather in neural ensembles within a trilaminar cortex similar to hippocampus. The olfactory system has tight, reciprocal links with both the limbic system and frontal cortex, and thus presents as an excellent model system for understanding a range of cognitive processes including memory, sensory perception, and emotional modulation and regulation, all of which are addressed in his lab.
Bibliographie brève
. Chapuis J, Wilson DA. Bidirectional plasticity of cortical pattern recognition and behavioral sensory acuity. Nature Neuroscience 2011 Nov 20;15(1):155-61.
. Wilson DA, Sullivan RM. Cortical processing of odor objects. Neuron. 2011 Nov 17;72(4):506-19.
Lundi 24 juin 2013 à 11h - Yi-Yuan TANG : Short-term meditation improves self-control and neuroplasticity: mechanism and clinical application
Salle de conférence, Bâtiment Inserm, 151 cours A. Thomas, Lyon 3ème
Proposition d'Antoine Lutz et des Equipes IMPACT et DYCOG.
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Yi-Yuan TANG Director, Texas Tech Neuroimaging Institute; Presidential Endowed Chair in Neuroscience; Professor, Department of Psychology, College of Arts & Sciences Dr. Yi-Yuan Tang is internationally known in the use of functional MRI (fMRI) to examine brain connectivity in cognitive task and found cultures shape math processing in the brain. Tang is the founder of Integrative Body-Mind Training (IBMT), a means for improving self-regulation and reducing or preventing various mental disorders. |
Thématiques de recherche
Dr Tang is a fellow of the Association for Psychological Science (APS), the Associate Editor of Social Cognitive & Affective Neuroscience (SCAN). He has published more than 200 internationally/nationally peer-reviewed articles in journals such as Proceedings of the National Academy of Sciences, Trends in Cognitive Sciences, Trends in Educational Neuroscience, Current Directions in Psychological Science, Social Cognitive & Affective Neuroscience, Cognitive, Affective & Behavioral Neuroscience, NeuroReport, Neuroscience Letters, Brain and Cognition, Brain Research, Progress in Brain Research, Child Development Perspectives, Stress and Health, Psychiatry Research, Neurocomputing, Neural Networks, Pattern Recognition Letters, Physica A, Human Brain Mapping and Neuroimage, etc.
Tang’s research applies the tools of neuroimaging, psychosocial and physiological measures (heart rate variability, skin conductance, etc.), as well as genetic analysis, and covers the topics in cultural neuroscience, cognitive, affective and social neuroscience, developmental neuroscience, body-mind medicine, prevention science, computational neuroscience, and neuroleadership.
Abstract
A series of research has shown that meditation training improves attention and self-control. However, the underlying mechanisms are still in debate.This talk will address the brain mechanisms using one form of brief meditation intervention, the Integrative body-mind training (IBMT) and also provide the applicable examples in mental disorders such as addiction.
Bibliographie brève
. Tang YY, Lu Q, Fan M, Yang Y, Posner MI. Mechanisms of white matter changes induced by meditation. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10570-4.. Tang YY, Rothbart MK, Posner MI. Neural correlates of establishing, maintaining, and switching brain states. Trends Cogn Sci. 2012 Jun;16(6):330-7.
. Tang YY, Lu Q, Geng X, Stein EA, Yang Y, Posner MI. Short-term meditation induces white matter changes in the anterior cingulate. Proc Natl Acad Sci U S A. 2010
Lundi 13 mai 2013 à 11h - David MEUNIER, Post-doctorant LabEx CORTEX, CRNL équipe CMO - Codage et Mémoire Olfactive.
Théorie des graphes pour l’étude des réseaux fonctionnels en neuroimagerie - (Graph theory for studying neuro-imaging functional networks)
Salle de conférence, Bâtiment Inserm, 151 cours A. Thomas, Lyon 3ème
Proposition de Jean-Pierre Royet et des Equipes CMO, DYCOG, IMPACT, NEUROPAIN.
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David MEUNIER Après une thèse de Sciences Cognitives à Lyon sur la modélisation de réseaux de neurones artificiels, David Meunier a effectué deux post-doctorats à l’université de Cambridge où il a appliqué les outils de la théorie des graphes à l’IRMf sur des sujets à l’état de repos, puis pour l’étude de processus psycholinguistiques. Il a ensuite effectué un post-doctorat à Orsay au LRI ou il a développé des méthodes de Machine Learning appliquées notamment à l’étude des données de neuro-imagerie. Il travaille actuellement au sein du CRNL, et applique la théorie des graphes à l’étude de la reconnaissance des odeurs en IRMf |
Abstract
L’étude des propriétés structure des réseaux fonctionnels suscitent un grand intérêt dans la communauté de la neuroimagerie. David Meunier passera en revue les méthodes d’analyse permettant d’étudier les propriétés au niveau de l’ensemble du cerveau ou sur des sous-réseaux d’intérêt. Il abordera également les applications sur des sujets à l’état de repos (resting-state) dans le cadre du vieillissement sain et de pathologies, et sur des sujets effectuant des tâches cognitives.
Bibliographie brève
. Meunier D, Achard S, Morcom A, Bullmore E (2009) « Age-related changes in modular organization of human brain functional networks ». NeuroImage, 44(3):715-23.
. Meunier D, Ersche KD, Craig KJ, Fornito A, Merlo-Pich EV, Fineberg NA, Shabbir SS, Robbins TW, Bullmore ET (2012), « Brain functional networks in stimulant drug dependence and obsessive-compulsive disorder » NeuroImage 59(2):1461-1468.
Lundi 25 mars 2013 à 11h - Michael POSNER : "Development of attention and self regulation"
Plus de 90 personnes ont pu assister à la 1ère conférence de ce nouveau cycle dans ce nouveau lieu.
Salle de conférence, Bâtiment Inserm, 151 cours A. Thomas, Lyon 3ème
This talk will deal with development in childhood and methods for aiding development in children and adults.
La conférence de M. Posner sera suivie d'une discussion avec le Dr Eric Sieroff de l'université Paris Descartes qui aborde l'attention d'un point de vue neuropsychologique.
Proposition d'Yves Rossetti et des Equipes IMPACT, CAP, NEUROPAIN, DYCOG.
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Michael Posner Professeur Emérite (2000) Université de l’Oregon USA « Institute of Cognitive and Decision Sciences » Professeur fondateur du Sackler Institute Weill Cornell Medical College New-York Board of Reviewing Editors, Science, 1988-1989 Membership National Academy of Sciences, 1992-94 Nominating Committee Society for Neuroscience, 1993 National Research Council Committee on Early Child Pedagogy, 1998-00 PNAS Board of Editors 2000 |
Thématiques de recherche
. Attention et Neurosciences Cognitives
. Etude des réseaux neuronaux sous-tendant l’attention, à l’aide de la psychophysique (temps de réaction), de la neuropsychologie (patients cérébro-lésés), de la neuroimagerie (PET, IRMf). En particulier : Rôle des circuits pariéto-frontaux et cingulo-operculaires
. Etude des fonctions exécutives, d’alerte, d’autorégulation.
. Etude développementale chez le nourrisson et l’enfant de l’efficacité des réseaux attentionnels: rôle combiné des variations génétiques et de l’expérience.
. Relations entre conscience et attention.
. Etude des effets neuro-fonctionnels de la méditation
Bibliographie brève
. Posner, MI. Orienting of attention (1980) : Qarterly Journal of Experimental Psychology 32, 3-25.
. Posner, MI; Walker, JA; Friedrich, FJ; et al. Effects of parietal injury on covert orienting of attention (1984) : Journal of Neuroscience, 4 (7), 1863-1874.
. Petersen, SE; Fox, PT; Posner, MI; et al. (1988) Positron emission tomographic studies of the cortical anatomy of single-word processing : Nature, 331 (6157) :585-589.
. Posner, MI; Petersen, SE. The attention system of the human brain (1990) : Annu. Rev. Neurosci., 13, 25-42.
. Bush, G; Luu, P; Posner, MI. Cognitive and emotional influences in anterior cingulate cortex (2000) : Trends in cognitive sciences,4 (6), 215-222.
. Posner MI. (2003) Imaging a science of mind. Trends Cogn Sci. 7(10), 450-3.
. Tang YY, Ma Y, Wang J, Fan Y, Feng S, Lu Q, Yu Q, Sui D, Rothbart MK, Fan M, Posner MI. (2007) Short-term meditation training improves attention and self-regulation. Proc Natl Acad Sci U S A. 104 (43), 17152-6.
. Fan, Jin; Hof, Patrick R.; Guise, Kevin G.; et al. The functional integration of the anterior cingulate cortex during conflict processing.(2008) Cerebral Cortex, 18 (4), 796-805.
. Tang YY, Posner MI. Attention training and attention state training.(2009) Trends Cogn Sci. 13(5):222-7.
. Tang YY, Lu Q, Geng X, Stein EA, Yang Y, Posner MI. (2010) Short-term meditation induces white matter changes in the anterior cingulate. Proc Natl Acad Sci U S A. 107 (35), 15649-52.
. Petersen SE ; Posner MI. The Attention System of the Human Brain: 20 Years After. (2012) Annu. Rev. Neurosci. 35:73–89
. Tang YY, Lu Q, Fan M, Yang Y, Posner MI. (2012) Mechanisms of white matter changes induced by meditation. Proc Natl Acad Sci U S A.;109(26):10570-4.
. Posner MI. (2012) Attentional networks and consciousness. Front Psychol. 2012;3:64.